Difference between revisions of "Template:NextTalk"

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Lecture Series: Mathematics and Data<br>
 
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July 11th - 14h00 <br>
 
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Conference Room (5.104)
 
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14h00 &emsp; Reconstructing phylogenetic trees in blood cancer - Dr. Thomas Stiehl<br>
 
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14h45 &emsp; Discussion on EPs further proceedings
 
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<b>Reconstructing phylogenetic trees in blood cancer</b>
 
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<i>Abstract: Leukemias (blood cancers) are characterized by a complex clinical course and a large inter-individual heterogeneity. Recent gene sequencing studies show that the leukemic cell bulk consists of multiple clones, each carrying a unique set of mutations. The genetic and phenotypic interdependence of the different clones is highly complex and so far not well understood. We develop a combinatorial tool to reconstruct all possible phylogenetic trees that are in line with given sequencing data. This is an important first step to understand the mechanisms underlying disease progression and treatment failure. We would like to discuss if topological methods can be applied to further improve the reconstruction of phylogenetic trees and which additional insights they could provide. As an example application we consider paired diagnosis-relapse samples from patients with acute myeloid leukemia. </i>
 
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<h4 style="margin:0px 0px 0.1em 0px;padding:0px">Summer School</h4>
 
<h4 style="margin:0px 0px 0.1em 0px;padding:0px">Summer School</h4>

Revision as of 15:08, 15 July 2019

Summer School

Persistent Homology and Barcodes

August 5-9

Schloß Rauischholzhausen
JLU Gießen

Organizers: Peter Albers (Heidelberg), Leonid Polterovich (Tel Aviv), Kai Zehmisch (Gießen)

website

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